Family

Bacterial DNA recombination protein RuvA (IPR000085)

Short name: RuvA

Overlapping homologous superfamilies

Family relationships

None.

Description

In prokaryotes, RuvA, RuvB, and RuvC process the universal DNA intermediate of homologous recombination, termed Holliday junction. The tetrameric DNA helicase RuvA specifically binds to the Holliday junction and facilitates the isomerization of the junction from the stacked folded configuration to the square-planar structure [PMID: 12408833]. In the RuvA tetramer, each subunit consists of three domains, I, II and III, where I and II form the major core that is responsible for Holliday junction binding and base pair rearrangements of Holliday junction executed at the crossover point, whereas domain III regulates branch migration through direct contact with RuvB.

GO terms

Biological Process

GO:0006310 DNA recombination
GO:0006281 DNA repair

Molecular Function

GO:0003678 DNA helicase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
PANTHER
HAMAP