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var(--colors-gray);color:#888;color:var(--colors-gray);cursor:pointer;font-size:.9rem;font-weight:900;line-height:1;margin:0 0 1rem;min-width:182px;padding:.85em 1em;position:relative;text-align:center;vertical-align:middle}.button-more:hover{color:#4b4b4b;color:var(--colors-dark)}.icon.button-more{font-weight:600}.icon.button-more:after,.icon.button-more:before{font-weight:300}.button-nu{color:#888;color:var(--colors-gray);font-size:160%;margin-right:1rem;min-width:25px;padding:0}.icon-common.icon-right:before{content:""}.icon-right:after{content:attr(data-icon);font-family:EBI-Common;position:absolute;right:.8rem;transition:all .1s ease-in-out;transition:all var(--timing-instant) ease-in-out}.icon-right:hover:after{right:.5em}.tabs.main-style{border-bottom:1px solid #e6e6e6;border-right-width:0;border-top-width:0}.tabs.main-style .tabs-title{margin-bottom:-1px}.tabs.main-style .tabs-title>a,.tabs.main-style .tabs-title>button{background:hsla(0,0%,87%,.54);border-top:3px solid hsla(0,0%,87%,.54);color:#676767;color:var(--colors-graydark)}.tabs.main-style .tabs-title>a:hover,.tabs.main-style .tabs-title>button:hover{background:#ddd;opacity:1}.tabs.main-style .tabs-title:last-of-type{border-right:1px solid #e6e6e6}.tabs.main-style .tabs-title.is-active>a,.tabs.main-style .tabs-title.is-active>a:focus,.tabs.main-style .tabs-title.is-active>button,.tabs.main-style .tabs-title.is-active>button:focus{background:#fff;border-top:3px solid #36aac0;color:#222;outline:none}.tabs.main-style .tabs-title.is-active>button:hover{background:#fff}.tabs.main-style .tabs-title a.is-active{background:#fff;border-top:3px solid #36aac0;color:#222;outline:none}.tabs .tabs-title.is-active>a,.tabs .tabs-title.is-active>a:focus,.tabs .tabs-title.is-active>button,.tabs .tabs-title.is-active>button:focus{background:#666;color:#fff}.tabs .tabs-title>a,.tabs .tabs-title>button{color:#0a0a0a;font-size:.75rem;line-height:1;padding:1.25rem 1.5rem}.tabs .tabs-title>a:hover,.tabs .tabs-title>button:hover{background:#ddd;opacity:.9}.tabs .tabs-title.is-active>button:hover{background:#666}.tabs.menu-style{border:0 solid #e6e6e6;margin-bottom:2rem}.tabs.menu-style .tabs-title{margin:0 1em 0 0}.tabs.menu-style .tabs-title>a{font-size:.9rem;line-height:inherit;padding:.7rem 1rem}.tabs.menu-style .tabs-title>a:hover{background-color:transparent;color:#1779ba;color:var(--colors-submain)}.tabs.menu-style .tabs-title>a.is-active-tab{background:#1779ba;color:#fff;font-weight:700}.tabs.menu-style~.tabs-content{border:0}.tabs.menu-style~.tabs-content .tabs-panel{padding:0}details.accordion-style>summary{border:1px solid #e6e6e6;border:solid var(--colors-very-white);border-width:1px 1px 0;color:#1779ba;color:var(--colors-submain);cursor:pointer;list-style:none;outline:0;padding:1rem;position:relative;z-index:1;z-index:var(--z-index-deepest)}details.accordion-style>summary:hover{background-color:#dedede;background-color:var(--colors-unknown-sub);color:#676767;color:var(--colors-graydark);transition:all .25s ease-out;transition:all var(--timing-fast) ease-out}details.accordion-style>summary:hover:after{background:#dedede;background:var(--colors-unknown-sub);transition:background-color .25s ease-out;transition:background-color var(--timing-fast) ease-out}details.accordion-style>summary:before{background:#1779ba;background:var(--colors-submain);transform:translateY(-50%) rotate(-45deg)}details.accordion-style>summary:after{background:#fff;margin-top:-3px;transform:translateY(-50%) rotate(-45deg)}details.accordion-style>summary::-webkit-details-marker{display:none}details.accordion-style>summary:after,details.accordion-style>summary:before{content:"";height:10px;position:absolute;right:20px;top:50%;width:10px}details.accordion-style:last-of-type{border-bottom:1px solid #e6e6e6;border-bottom:1px solid var(--colors-very-white)}.accordion-info{border:1px solid #eee;border:1px solid var(--colors-nearly-white);border-top:0 solid var(--colors-nearly-white);padding:1rem}.accordion-info p:last-of-type{margin-bottom:0}details.accordion-style[open]>summary{background-color:#78d2dd;background-color:var(--colors-accordion);color:#fff}details.accordion-style[open] summary~*{-webkit-animation:sweep .2s ease-out;animation:sweep .2s ease-out;-webkit-animation:sweep var(--timing-really-fast) ease-out;animation:sweep var(--timing-really-fast) ease-out}details.accordion-style[open] summary:after{background:#78d2dd;background:var(--colors-accordion);content:"";margin-top:-2px;transform:rotate(45deg)}details.accordion-style[open] summary:before{transform:translateY(-50%) rotate(45deg)}details.option-style>summary{border:0 solid #e6e6e6;border:0 solid var(--colors-very-white);color:#676767;color:var(--colors-graydark);cursor:pointer;list-style:none;outline:0;padding:1rem;position:relative;z-index:1;z-index:var(--z-index-deepest)}details.option-style>summary,details.option-style>summary:hover{transition:all .4s ease-out;transition:all var(--timing-medclose) ease-out}details.option-style>summary:hover{background-color:#dedede;background-color:var(--colors-unknown-sub);color:#4b4b4b;color:var(--colors-dark)}.local_footer{padding:1rem 0}.local_footer ul.off-canvas-list{background-color:transparent}.local_footer ul.off-canvas-list label{background-color:transparent;border-top:0 solid #fff;color:#baf7d5;font-size:.9rem}.local_footer.masthead ul.off-canvas-list a:visited.active{color:rgba(68,68,68,.6)}.local_footer.masthead img.logo_faint{margin-left:0;margin-right:0;opacity:.4;width:170px}.local_footer.masthead h1{color:#000;opacity:.4}.local_footer .is-drilldown-submenu{background-color:#509394}.local_footer.masthead{background-size:130%,110%}.clanviewer{width:100%}.clanviewer g text{fill:#09436b}.clanviewer g.node circle{fill:#1f77b4;stroke:#186092;stroke-width:1px}.clanviewer g.node:hover circle{stroke:#2199e8;fill:#2199e8;cursor:pointer}.clanviewer g.node:hover text{fill:#2199e8;cursor:pointer}.clanviewer g.link text{fill:#aaa}.clanviewer g.link:hover text{font:10px sans-serif}.clanviewer g.link path{stroke:#aaa}.clanviewer g.link:hover path{stroke:#e8df8a;stroke:var(--colors-markchart)}.card-info-author .button.hollow.secondary{border-color:transparent;padding:.4rem 0}.card-info-author .button.hollow.secondary i{display:none}.card-info-author .margin-bottom-large{margin:0}@media screen and (max-width:20em){.local-offcanvas-menu,.local-site-search{opacity:0}}.image-funding{padding:1em}.image-funding-embl{background:#fff url(/interpro/assets/images/logo_embl.2ca.png) no-repeat 50% 14%;background-size:30%}.image-funding-wellcome-trust{background:#fff url(/interpro/assets/images/logo_wellcome.5e9.jpg) no-repeat 50% 14%;background-size:30%}.image-funding-bbsrc{background:#fff url(/interpro/assets/images/logo_bbsrc.89e.png) no-repeat 50% 14%;background-size:30%}.radio-btn{opacity:0;position:absolute;visibility:hidden}.radio-btn-label{align-items:center;color:#1779ba;color:var(--colors-submain);cursor:pointer;display:flex;font-size:1.25rem;padding:.05rem 0;text-transform:capitalize;transition:all .25s linear}.radio-btn-label.checked{font-weight:700}.radio-btn-label.checked:before{background:#1779ba;background:var(--colors-submain);border:.4rem solid #1779ba;border:.4rem solid var(--colors-submain);margin-right:.5rem}.radio-btn-label:not(.checked):hover:before{margin-right:.8rem}.radio-btn-label:before{border:.2rem solid #1779ba;border:.2rem solid var(--colors-submain);border-radius:50%;content:"";display:inline-block;height:.8rem;margin-right:1rem;min-width:.8rem;transition:all .25s linear;width:.8rem}.no-padding{padding:0}
:root{--timing-instant:0.1s;--timing-really-fast:0.2s;--timing-fast:0.25s;--timing-medclose:0.4s;--timing-medium:0.5s;--timing-slow:1s;--timing-really-slow:2s;--timing-fn-spring:cubic-bezier(0.43,1.34,0.7,1.15)}.Loading_style__loading-spinner___b4{-webkit-animation:Loading_style__appear___fd .5s ease-in-out .25s 1 normal both;animation:Loading_style__appear___fd .5s ease-in-out .25s 1 normal both;-webkit-animation:Loading_style__appear___fd var(--timing-medium) ease-in-out var(--timing-fast) 1 normal both;animation:Loading_style__appear___fd var(--timing-medium) ease-in-out var(--timing-fast) 1 normal both;font-size:10px;height:50px;margin:100px auto;text-align:center;width:200px}@-webkit-keyframes Loading_style__appear___fd{0%{opacity:0}to{opacity:1}}@keyframes Loading_style__appear___fd{0%{opacity:0}to{opacity:1}}.Loading_style__loading-spinner___b4>div{-webkit-animation:Loading_style__stretchdelay___e3 1.1s ease-in-out infinite;animation:Loading_style__stretchdelay___e3 1.1s ease-in-out infinite;background-color:#000;border-radius:50%;display:inline-block;height:40%;margin-right:.2rem;width:21px}.Loading_style__loading-spinner___b4>div:first-child{-webkit-animation-delay:-1.2s;animation-delay:-1.2s}.Loading_style__loading-spinner___b4>div:last-child{-webkit-animation-delay:-1s;animation-delay:-1s}@-webkit-keyframes Loading_style__stretchdelay___e3{0%,40%,to{opacity:.3;transform:scale(.5)}20%{opacity:.6;transform:scale(1)}}@keyframes Loading_style__stretchdelay___e3{0%,40%,to{opacity:.3;transform:scale(.5)}20%{opacity:.6;transform:scale(1)}}.Loading_style__loading-spinner___b4.Loading_style__inline___a7{height:1em;margin:0}.Loading_style__loading-spinner___b4.Loading_style__inline___a7>div{height:.8em;margin-right:.2em;width:.8em}
:root{--z-index-zero:0;--z-index-deepest:1;--z-index-deep:2;--z-index-just-over:5;--z-index-over:5;--z-index-memberdb:20;--z-index-main-menu:50;--z-index-over-main:80;--z-index-interpro-header:100;--z-index-ebi-header:200;--z-index-side-menu:250;--z-index-toasts:300;--z-index-toasts-on-hover:350;--z-index-modal:1000}.Overlay_style__overlay___d5{background:#000;cursor:pointer;height:100vh;left:0;opacity:0;pointer-events:none;position:fixed;top:0;transition:opacity .3s ease-in-out;width:100%;z-index:5;z-index:var(--z-index-over)}.Overlay_style__visible___e0{cursor:pointer;opacity:.2;pointer-events:auto}
.Sentinel_style__sentinel___ca{height:1px;pointer-events:none;position:absolute;width:100%}
.EBIHeader_style__masthead-black-bar___c8 a:visited{color:#fff}.EBIHeader_style__global-nav___cb>*{float:none!important}.EBIHeader_style__global-nav___cb>.EBIHeader_style__embl-selector___c3{float:right!important}.EBIHeader_style__global-nav___cb>.EBIHeader_style__embl-selector___c3>button{cursor:pointer!important}.EBIHeader_style__global-nav___cb>.EBIHeader_style__embl-selector___c3>button:after{content:none!important}.EBIHeader_style__home-mobile___b1 a{color:transparent!important;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}
@font-face{font-family:EBI-Common;font-style:normal;font-weight:400;src:url(/interpro/assets/fonts/EBI-Common.03a.woff2) format("woff2"),url(/interpro/assets/fonts/EBI-Common.54f.woff) format("woff")}@font-face{font-family:EBI-Conceptual;font-style:normal;font-weight:400;src:url(/interpro/assets/fonts/EBI-Conceptual.863.woff2) format("woff2"),url(/interpro/assets/fonts/EBI-Conceptual.64d.woff) format("woff")}@font-face{font-family:EBI-Species;font-style:normal;font-weight:400;src:url(/interpro/assets/fonts/EBI-Species.f80.woff2) format("woff2"),url(/interpro/assets/fonts/EBI-Species.50a.woff) format("woff")}@font-face{font-family:EBI-FileFormats;font-style:normal;font-weight:400;src:url(/interpro/assets/fonts/EBI-FileFormats.a9f.woff2) format("woff2"),url(/interpro/assets/fonts/EBI-FileFormats.c49.woff) format("woff")}@font-face{font-family:EBI-Chemistry;font-style:normal;font-weight:400;src:url(/interpro/assets/fonts/EBI-Chemistry.241.woff2) format("woff2"),url(/interpro/assets/fonts/EBI-Chemistry.c59.woff) format("woff")}

/* !LEGACY! We recommend using EBI-Common
 * See note at https://github.com/ebiwd/EBI-Icon-fonts/issues/22
 */@font-face{font-family:EBI-Functional;font-style:normal;font-weight:400;src:url(/interpro/assets/fonts/EBI-Functional.3e9.woff2) format("woff2"),url(/interpro/assets/fonts/EBI-Functional.b49.woff) format("woff")}

/* !LEGACY! We recommend using EBI-Common
 * See note at https://github.com/ebiwd/EBI-Icon-fonts/issues/22
 */@font-face{font-family:EBI-Generic;font-style:normal;font-weight:400;src:url(/interpro/assets/fonts/EBI-Generic.e6e.woff2) format("woff2"),url(/interpro/assets/fonts/EBI-Generic.39d.woff) format("woff")}

/* !LEGACY! We recommend using EBI-Common
 * See note at https://github.com/ebiwd/EBI-Icon-fonts/issues/22
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