{"metadata":{"accession":"M6UP48","id":"M6UP48_9LEPT","source_organism":{"taxId":"1049985","scientificName":"Leptospira santarosai str. ZUN179","fullName":"Leptospira santarosai str. ZUN179"},"name":"Oxygen sensor histidine kinase NreB","description":["Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT"],"length":356,"sequence":"MRDPKRKTGKSLSPPIILKSGLSPKFFLNLLKEISPIVAIDDKRAILFANESFRKEFAGNSRNLMGKNLFRIFGLNPVDQEEMESNIKLSKKGMVQNQEFKKQKIYYGYSVFRFGESIGIILKNITENKRLEKKIANLHTKLLQSQEEERIRLSRELHDGVGQTILAAKLNFQAYNRNPKVYGAQFDTGLLLIDKASQELRDIYTNLHPSTLREIGLEAAIRALSSDLFPPMDVEADLDLNLKRDLEPAIANQIFRIVQEIFQNVIKHSQARKIYLKVHVKGRQLFLDAKDNGIGFQEKKARVKSSGFGLENIRRRVEDLNGKFKIDSSSGEGTKFIVRIPLEKTKTHSPKKYENY","proteome":null,"gene":"LEP1GSC187_0937","go_terms":[{"identifier":"GO:0000155","name":"phosphorelay sensor kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0046983","name":"protein dimerization activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000160","name":"phosphorelay signal transduction system","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0016772","name":"transferase activity, transferring phosphorus-containing groups","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016310","name":"phosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"2cbb28090dd09ba9eade30e5c42440c887294ac5","counters":{"domain_architectures":55892,"entries":17,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"pfam":2,"profile":1,"ssf":1,"smart":1,"cdd":1,"panther":1,"prints":1,"interpro":6},"proteome":0,"taxonomy":1,"similar_proteins":55892}}}