{"metadata":{"accession":"H3AFK8","id":"H3AFK8_LATCH","source_organism":{"taxId":"7897","scientificName":"Latimeria chalumnae","fullName":"Latimeria chalumnae (Coelacanth)"},"name":"Glycoprotein hormones alpha chain","description":["Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism"],"length":129,"sequence":"IMSALRVGTVTLLIALMISESWNYETLGPGCHLHAFNVTIKSDRRGTCRGTHMIHACVGYCESSAFPSKYSVLVASNFKHNITSVSQCCTISKKQKIKVRLHCGGARREEIEIFTAKACQCDMCRLSRY","proteome":"UP000008672","gene":"GPHA2","go_terms":[{"identifier":"GO:0005179","name":"hormone activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005576","name":"extracellular region","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c41de36a481f7d27550f55756c70e925da8ec8a1","counters":{"domain_architectures":1246,"entries":10,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"profile":2,"cathgene3d":1,"pfam":1,"ssf":1,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":1246}}}