{"metadata":{"accession":"G5BWK2","id":"G5BWK2_HETGA","source_organism":{"taxId":"10181","scientificName":"Heterocephalus glaber","fullName":"Heterocephalus glaber (Naked mole rat)"},"name":"Nicastrin","description":["Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels"],"length":709,"sequence":"MATAGGSSEADPGSRGLLRLLSFCVLLAGLCKGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSINGDTGVIHVVEKEEDLRWVLTDGPNPPYMVLLEGKLFTRHIMEKLKGKNSRIAGLAVTLAKPSPTPGFSPSVQCPNDGFGVYSNSYGSEFAHCKEKPWNPLGSGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPAFPLCAMQLFSHMHAVISTATCMRRSFIQSTFSINPEIVCDPLSDYNVWSMLKPINTSGTLEPDERVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVRLENIDSFVELGQVALRTSLELWMHTDPMSQKNESVRNQVEDLLATLERSGADVPDVILRRINQSHALPPSSLQRFLRAQNISGVVLADHNDSFHNLYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALANVATVLGRALYVLAGGSNFSNTVEADPQTVTRLLYGFLIQANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGKVIDLTREQCQDPSKVPNENKDLYEYSWVQGPLSSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIFLIASKELEFITLMVGFGILVFSLIVTYCINAKADVLFIAPREPGAVSY","proteome":"UP000694906","gene":"Ncstn","go_terms":[{"identifier":"GO:0016485","name":"protein processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f17f9a777791b135feb7411b63bc57824c683eee","counters":{"domain_architectures":2795,"entries":8,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"cdd":1,"ssf":1,"cathgene3d":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":2795}}}