{"metadata":{"accession":"G1SLB5","id":"G1SLB5_RABIT","source_organism":{"taxId":"9986","scientificName":"Oryctolagus cuniculus","fullName":"Oryctolagus cuniculus (Rabbit)"},"name":"Monocyte differentiation antigen CD14","description":["Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-)"],"length":372,"sequence":"MEPVPCLLLLLLPLLRASTDTPEPCELDDDDIRCVCNFSDPQPDWSSALQCMPAVQVEMWGGGHSLEQFLRQADLYTDQRRYADVVKALRVRRLTVGAVQVPAPLLLGVLRVLGYSRLKELALEDIEVTGTAPPPPPLEATGPALSTLSLRNVSWPKGGAWLSELQQWLKPGLQVLNIAQAHTLAFSCEQVRTFSALTTLDLSENPGLGERGLVAALCPHKFPALQDLALRNAGMKTLQGVCAALAEAGVQPHHLDLSHNSLRADTQGCIWPSALNSLNLSFTGLQQVPKGLPAKLNVLDLSCNKLNRAPQPGELPKVVNLSLDGNPFLVPGASKLQEDLTNSGVFPACPPSPLAMGMSGTLALLQGARGFI","proteome":"UP000001811","gene":"CD14","go_terms":null,"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":null,"counters":{"domain_architectures":0,"entries":6,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pirsf":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1}}}