{"metadata":{"accession":"G1QRB6","id":"G1QRB6_NOMLE","source_organism":{"taxId":"61853","scientificName":"Nomascus leucogenys","fullName":"Nomascus leucogenys (Northern white-cheeked gibbon)"},"name":"Terpene cyclase/mutase family member","description":["Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency"],"length":672,"sequence":"KNYFKDLPKARTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYAIRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYERHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQTRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPYVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALQYFQKHFPDHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYQDGTACAAVSRACDFLLSRQMADGGWGEDFESCEERRYVQSAQSQIHNTCWALMGLMAVRHPDVEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFSQLYPERALAGRP","proteome":"UP000001073","gene":"LSS","go_terms":[{"identifier":"GO:0016866","name":"intramolecular transferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016104","name":"triterpenoid biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005811","name":"lipid droplet","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"fe706c2f3b875402e9715ad107d41911d57a055e","counters":{"domain_architectures":10961,"entries":14,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"cathgene3d":1,"pfam":2,"ssf":1,"panther":1,"sfld":1,"ncbifam":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":10961}}}