{"metadata":{"accession":"Q6JLX1","id":"IGF1_AILME","source_organism":{"taxId":"9646","scientificName":"Ailuropoda melanoleuca","fullName":"Ailuropoda melanoleuca (Giant panda)"},"name":"Insulin-like growth factor 1","description":["The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity). As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity)"],"length":153,"sequence":"MGKISSLPTQLFKCCFCDFLKVKMHIMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKAQKEVHLKNASRGSAGNKNYRM","proteome":"UP000008912","gene":"IGF1","go_terms":[{"identifier":"GO:0005179","name":"hormone activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005576","name":"extracellular region","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0008083","name":"growth factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005615","name":"extracellular space","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"b9ca085d0992375b116a007d7162409be3587261","counters":{"domain_architectures":6728,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"cdd":1,"pfam":1,"smart":1,"panther":1,"prints":3,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":6728}}}