{"metadata":{"accession":"Q06AS9","id":"EFNA1_PIG","source_organism":{"taxId":"9823","scientificName":"Sus scrofa","fullName":"Sus scrofa (Pig)"},"name":"Ephrin-A1","description":["Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Involved in angiogenesis, regulating vascular endothelial cell differentiation and migration through activation of EPHA2. Acts as a ligand for EPHA3, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development. May also contribute to dendritic spine morphogenesis"],"length":205,"sequence":"MEFLWAPLLGLCCSLAAADRHTVFWNSSEPKFWNEDYTVHVRLNDYLDIICPHYEDDSVAEAAMERYTLYLVEREQYQLCQPQSKDQVRWQCNQPNARHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHHQEDQCLKLKVTVSGKITHSPQAHANPQEKRLPADDPEVQVLHSIGHSAAPRLSPLAWAVLLLPFLLLQTS","proteome":"UP000008227","gene":"EFNA1","go_terms":[{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0046875","name":"ephrin receptor binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0048013","name":"ephrin receptor signaling pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"8209c025ff4ca30f35b2f3c8ca3610205b6ca4c1","counters":{"domain_architectures":8598,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"pfam":1,"ssf":1,"cathgene3d":1,"profile":1,"cdd":1,"panther":1,"prints":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":8598}}}