{"metadata":{"accession":"P70597","id":"PE2R1_RAT","source_organism":{"taxId":"10116","scientificName":"Rattus norvegicus","fullName":"Rattus norvegicus (Rat)"},"name":"Prostaglandin E2 receptor EP1 subtype","description":["Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function (By similarity). Implicated the smooth muscle contractile response to PGE2 in various tissues. Isoform 1 and isoform 2 have identical ligand binding properties, but isoform 2 lacks coupling to calcium mobilization and may therefore attenuate the action of PGE2 on tissues"],"length":405,"sequence":"MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL","proteome":"UP000002494","gene":"Ptger1","go_terms":[{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004957","name":"prostaglandin E receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004955","name":"prostaglandin receptor activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"587fa3dbe4504dc051049f3cca904dd9ab631b87","counters":{"domain_architectures":394800,"entries":14,"isoforms":2,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"profile":1,"pfam":1,"panther":1,"prints":3,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":394800}}}