{"metadata":{"accession":"P41807","id":"VATH_YEAST","source_organism":{"taxId":"559292","scientificName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","fullName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)"},"name":"V-type proton ATPase subunit H","description":["Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:27295975, PubMed:8349704). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:27295975, PubMed:8349704). This subunit is essential for activity, but not assembly, of the enzyme complex (PubMed:27295975, PubMed:8349704). This subunit is also required for silencing the ATPase activity of V-ATPase when V1 is detached from V0 (PubMed:27295975)"],"length":478,"sequence":"MGATKILMDSTHFNEIRSIIRSRSVAWDALARSEELSEIDASTAKALESILVKKNIGDGLSSSNNAHSGFKVNGKTLIPLIHLLSTSDNEDCKKSVQNLIAELLSSDKYGDDTVKFFQEDPKQLEQLFDVSLKGDFQTVLISGFNVVSLLVQNGLHNVKLVEKLLKNNNLINILQNIEQMDTCYVCIRLLQELAVIPEYRDVIWLHEKKFMPTLFKILQRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTFNPVFANELVQKYLSDFLDLLKLVKITIKEKVSRLCISIILQCCSTRVKQHKKVIKQLLLLGNALPTVQSLSERKYSDEELRQDISNLKEILENEYQELTSFDEYVAELDSKLLCWSPPHVDNGFWSDNIDEFKKDNYKIFRQLIELLQAKVRNGDVNAKQEKIIIQVALNDITHVVELLPESIDVLDKTGGKADIMELLNHSDSRVKYEALKATQAIIGYTFK","proteome":"UP000002311","gene":"VMA13","go_terms":[{"identifier":"GO:0046961","name":"proton-transporting ATPase activity, rotational mechanism","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:1902600","name":"proton transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0000221","name":"vacuolar proton-transporting V-type ATPase, V1 domain","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"710f75c48e95a31c6aa128560e2a5657f5a966b2","counters":{"domain_architectures":5098,"entries":12,"isoforms":0,"proteomes":1,"sets":1,"structures":23,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":1,"pfam":2,"pirsf":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":5098}}}