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InterPro-Version: 109.0
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{
    "metadata": {
        "accession": "W5UBY4",
        "id": "W5UBY4_ICTPU",
        "source_organism": {
            "taxId": "7998",
            "scientificName": "Ictalurus punctatus",
            "fullName": "Ictalurus punctatus (Channel catfish)"
        },
        "name": "non-specific serine/threonine protein kinase",
        "description": [
            "Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis"
        ],
        "length": 483,
        "sequence": "MTERREHVQLRNNPRRQLKKLSEDSLTKQPEEVFDILEKLGEGSYGSVFKAHYKETGEIVAIKQVPVESDLQEIIKEISIMQQCNSPHVVRYYGSYFKNSDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIAAIVQSTLKGLEYLHFMRKIHRDIKAGNILLNSEGQAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRNPDQWSETFKDFVSQCLIKNPENRATATQLLQHAFIKSAKSNSILRALITEAMEIKLKKQETQQREQDAEDEENSDEDEVDQGTMVRASTSDLGTVRAAGSLRSSLGTMIEHNDSTLDSQLGTMVINSEDEQEDAGTMKHHQETMQPAKPSFLQYFEQKEKEDNKNSDNDSHKLPPEGDMEVIRSLSVEELRRRLASLDPQMEQEIEEIHQRYQAKRQPILDAIEAKKRRQQNF",
        "proteome": null,
        "gene": "STK4",
        "go_terms": [
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006468",
                "name": "protein phosphorylation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0051262",
                "name": "protein tetramerization",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0007165",
                "name": "signal transduction",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0004674",
                "name": "protein serine/threonine kinase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 2,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "ida_accession": "f661b271fc0d7852498aeeba81005c4217032105",
        "counters": {
            "domain_architectures": 2592,
            "entries": 20,
            "isoforms": 0,
            "proteomes": 0,
            "sets": 3,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 3,
                "cdd": 2,
                "ssf": 1,
                "profile": 2,
                "smart": 1,
                "pfam": 2,
                "panther": 1,
                "prosite": 1,
                "interpro": 7
            },
            "proteome": 0,
            "taxonomy": 1,
            "similar_proteins": 2592
        }
    }
}