{"metadata":{"accession":"U7Q0Y9","id":"U7Q0Y9_SPOS1","source_organism":{"taxId":"1391915","scientificName":"Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183)","fullName":"Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's disease fungus)"},"name":"Sulfite efflux pump SSU1","description":["Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine"],"length":528,"sequence":"MSALIPEFSTASPDGSGIFFHTLRQANASEENVDTSDHVNNTSCSAGTTADAAPTLRESDPEKDAESSPAVPVVSNISSHDTINASAENGSHPVSRSHSNAVAELPTANTPCAGAGDSDIRILPCGAVVATNERENRGWRKIVRNFTPSWFSVCMGTGVVAILLHNLPYNAHWVWYLSVAVFCLNILLFITFSLITITRYVVYPEIWNVMIKHPSQSLFLGCIPMAFSTIVTMMALVCTTWGNWAIYLIWAFWWVDVFGSCACSLIIPFVIIHHHRNQLSHMTAALLLPVVPVIVAAASGSVIAEALPNRSHQLTTLVLSYIIWGLGETFSFFIMTVYFLRLQIHDLPPREVIVSVFLPIGPLGQGGFAIQQLGKLAMQVLPATGAFNGAIPDGTSPNALDATALYGPTVLYMIGILAGFFLWGAALGWLAFAIISIMTTKSFPFNMGWWGFVFPLGVFTSCTGVLAVELSSTFFKVITMIFSALVFCLWILVAVKTTIMVYRGNMFYAPCLRDLHPKEEQPGGKRTV","proteome":"UP000018087","gene":"HMPREF1624_02810","go_terms":[{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"804e7d458aceaacafb773626718062eaa40bc470","counters":{"domain_architectures":20069,"entries":7,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"panther":1,"pfam":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":20069}}}