{"metadata":{"accession":"T1H9E1","id":"T1H9E1_RHOPR","source_organism":{"taxId":"13249","scientificName":"Rhodnius prolixus","fullName":"Rhodnius prolixus (Triatomid bug)"},"name":"Cytosol aminopeptidase","description":["Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status"],"length":426,"sequence":"GKNVIVAGLGKRDEWDENKELNIGGKIYCELSRLKIKQAAISIEGNAANVAYGAFLRSFKFDKYKTKKDEKVTEVEEITVLAKDEQFSSAEKSFKCLRQEGEGIFLARALTTEPPNVLYPESYADYIKTELTKLGLEIEVLGKKQMEEKKMGALLGVAQGSSKEPKLVVIKWNGASKEQKPVAFVGKGITFDTGGVSLKPSRGMESMKYDMAGSATVVGVMRTLTGRKAKVNAIGVVALAENAVDGNAQRPSDVVTSMSGQTIEVLNTDAEGRLILADALWYTQNRFSPKFMVDLATLTGAIVVALGNNEYAGLFSNNDELVNRLTNAGNEVNEKLWRFPMNETYDKIIDSPIADVQNIAPAGSGGDSIMAAQFLQRFVNETCWAHLDIAGTAWHEKGTDISPKGAVGFGIRLLNKLVEKYYETGN","proteome":"UP000015103","gene":null,"go_terms":[{"identifier":"GO:0030145","name":"manganese ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0070006","name":"metalloaminopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019538","name":"protein metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0006508","name":"proteolysis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0046872","name":"metal ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"5e69a2aa28cd056abaf8be0fdbafffbba4d7d13d","counters":{"domain_architectures":22296,"entries":20,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"cdd":1,"pfam":2,"ssf":2,"ncbifam":4,"hamap":1,"panther":1,"prosite":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":22296}}}