{"metadata":{"accession":"R0I7B8","id":"R0I7B8_EXST2","source_organism":{"taxId":"671987","scientificName":"Exserohilum turcicum (strain 28A)","fullName":"Exserohilum turcicum (strain 28A) (Northern leaf blight fungus)"},"name":"Squalene synthase","description":["Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene","Squalene synthase; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS). Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. The presence of a gene encoding a squalene synthase supports the identification of the cluster as being responsible for SQS1 production and suggests a likely mechanism for self-resistance"],"length":484,"sequence":"MPSPLSLLYYVGHPGELRSIIQWKVWHNPVHERDEAKETESLKRCFHFLHLTSRSFTAVILELHPELLVPVTLFYLALRGLDTIEDDMTLHLQKKEPLLRNFQEVLEQDGWNFTENGPNEKDRQLLVEFHVVIEEYKKLKPAYKDIIKDITKRMGNGMADYAKNAEFNAGVKTIKEYELYCHYVAGLVGEGCTRLFVEAGLANEALLKKPELMESMGQFLQQVNITRDIKEDFDDGRRFWPKEIWSKHVDNFEDLFKPENKQKALNASSEMILTALTRADDCLYYLAGLREQSVFNFCAIPQSMAIATLEACFQNYALFQKNVKITKGEACQLMVESTQNLQLVCQVFRRYARKIAKKNNPHDPNFLKISITLGRIEQFIESIFPSQQPPVDRKAPATIEEAAKKRKEDSEANWDLIYVVAAVVGTVLVMTTLMLGIAWLAGARFDIAWSQARQDISKVLNMGASQAPAQVTQVLETVVEKSEL","proteome":"UP000016935","gene":"SETTUDRAFT_174109","go_terms":[{"identifier":"GO:0051996","name":"squalene synthase [NAD(P)H] activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009058","name":"biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0045338","name":"farnesyl diphosphate metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008610","name":"lipid biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016765","name":"transferase activity, transferring alkyl or aryl (other than methyl) groups","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7ee50707bedad879bc606a96fc69cbee4c35c950","counters":{"domain_architectures":33932,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"pfam":1,"panther":1,"sfld":2,"ncbifam":1,"prosite":2,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":33932}}}