{"metadata":{"accession":"Q9ZCB3","id":"RFTRM_RICPR","source_organism":{"taxId":"272947","scientificName":"Rickettsia prowazekii (strain Madrid E)","fullName":"Rickettsia prowazekii (strain Madrid E)"},"name":"Bifunctional methyltransferase","description":["Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif","Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA"],"length":518,"sequence":"MQYSIKQILSNANDKLNKIGINLPGLEARILLQHVTNKPIEHLLIKLNEQLSEAEIEAFEKLLERRLAHEPIAYIIGVKEFYSREFIVNKHVLIPRIDTEVLVDVVIGLVVSRNNLHMFSKLKSLDSVLTTQSYNILELGTGSGCIAISLLCELPNTNIIATDISVDAIKVAKSNSIKYNVTDRIQIIHSNWFEKLDKQKFDFIVSNPPYISHTEKLKMAIETINYEPSIALFAEEDGLEAYSIIAKNAKQFLKPNGKIILEIGFSQAAKVSKIFLNYGYNIDYIYRDLQSHNRVIEISPINLNRSYARRIGKSLSKMQQKLLDNELPKYLFSKEKFKSEKRKVFLEIGFGMGEHLINQAKINPDTLFIGVEVYLNGVANVLKHSAQHNITNFLLFPNNLDLILNDLPNNSLDGIYILFPDPWIKNKKKKKRIFNKERLKILQNKLKNNGNLVFASDIENYFYEAMALIRQNGNFEIIHNDDYLQPHDNYIITKYHQKAINANRTAKFMILQHALTDH","proteome":"UP000002480","gene":"prmC/trmB","go_terms":[{"identifier":"GO:0008168","name":"methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008176","name":"tRNA (guanine(46)-N7)-methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006400","name":"tRNA modification","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008276","name":"protein methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006479","name":"protein methylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0032259","name":"methylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"5bad5a91fb85c680b4c79503c968976dc3b324bb","counters":{"domain_architectures":35,"entries":25,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":1,"pfam":3,"cdd":1,"profile":1,"ncbifam":4,"panther":1,"hamap":2,"prosite":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":35}}}