{"metadata":{"accession":"Q9Y5K5","id":"UCHL5_HUMAN","source_organism":{"taxId":"9606","scientificName":"Homo sapiens","fullName":"Homo sapiens (Human)"},"name":"Ubiquitin carboxyl-terminal hydrolase isozyme L5","description":["Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1"],"length":329,"sequence":"MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNAKKAQETK","proteome":"UP000005640","gene":"UCHL5","go_terms":[{"identifier":"GO:0004843","name":"cysteine-type deubiquitinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006511","name":"ubiquitin-dependent protein catabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0070628","name":"proteasome binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016579","name":"protein deubiquitination","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0031011","name":"Ino80 complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"8ee7d6d4c7be4bc8b88c097d3270df4c9225d658","counters":{"domain_architectures":5948,"entries":17,"isoforms":4,"proteomes":1,"sets":3,"structures":11,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":1,"profile":2,"pfam":2,"cdd":1,"pirsf":1,"panther":1,"prints":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":5948}}}