{"metadata":{"accession":"Q9XUS7","id":"TOCA2_CAEEL","source_organism":{"taxId":"6239","scientificName":"Caenorhabditis elegans","fullName":"Caenorhabditis elegans"},"name":"Transducer of Cdc42-dependent actin assembly protein 2 homolog","description":["Plays a role in protein trafficking, actin organization and embryonic morphogenesis (PubMed:19798448). Potentially acts as a cdc-42 effector (PubMed:25775511). May play a role in egg laying (PubMed:19798448). Together with toca-1, is required for protein trafficking regulating yolk protein clathrin-mediated endocytosis by oocytes during oogenesis and retrograde recycling and the sorting of recycling endosome cargo proteins such as mig-14 (PubMed:19798448, PubMed:25775511). Also, together with toca-2, controls the distribution of actin at cell junctions (PubMed:19798448, PubMed:26578656)"],"length":610,"sequence":"MIPVSRFFTVQDPSNALLSYTQKGIDFFEKLGQFSKEKAAIEEEYSTKLRSLAKKYAKKSEEDDEILKSVSYTSSFNSFLQQLDQIATRHQTSAEHIRGGVVSYVASKTCQMRSSRKNAINDLKTINDKLEDQINEMCKSGKCYLKSFKDAENSYQKFYKADKNLEISRLELEKARALANARNEACELAKQDYSALVRKTNAEQKRYHVELLPVIFARLKAVDKECIADMRQVLQKIVSFDDSLADSTEECRKIMQREVGKIDAEGDAQLVLKSVEATIEQPAPFEIEDLGDPKNCDSRTNDSADGSGGKLLKSSPSKNRIIRNFLGILKEKEADEKPEASNNDQLMYTDKSKPAHVRLSCLRSKIRDMEKQLEQAIQGREGITRLQQAYYTNPQHGNPSACTEPLISYAKKIEKLKMDIHNLKEFYAMLEMSVEEGQERSFGGRDTPDTTRSMSGSSTNQSSSKTIEDVLSGEAGNSSSADDSSKNILRQLFTTPKRLISSPKTSKSSTPTPLRRRAEISSPKILRSSFSGAIRKSLSTPDSVKVETAVTVTALFEFAKSSAETMSIEQGEILLVLEHDHGDGWTRTKNCRKHNEESGFVPTSYLQFPQ","proteome":"UP000001940","gene":"toca-2","go_terms":[{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"bdc518c2f383f4ff7f7c48097c1e48e4f8ff3dd3","counters":{"domain_architectures":6390,"entries":24,"isoforms":2,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"profile":3,"cdd":3,"smart":2,"cathgene3d":3,"ssf":2,"pfam":3,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":6390}}}