{"metadata":{"accession":"Q9VZJ9","id":"MUL1_DROME","source_organism":{"taxId":"7227","scientificName":"Drosophila melanogaster","fullName":"Drosophila melanogaster (Fruit fly)"},"name":"Mitochondrial E3 ubiquitin protein ligase 1","description":["Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fission. Negatively regulates the mitochondrial fusion protein marf by promoting its ubiquitination, acting in a pathway that is parallel to the park/pink1 regulatory pathway"],"length":338,"sequence":"MEFLHESVALGVDLLILGLCAREYVHYKRTAKVLKAAPQYNIDGDLKSVVERQRDKKIPYAVIRGTVTPIGVPLRSSLVPSVSGVLQIVKLHEHRVTRGFAGFWTEQHKLLHESANEMPFELRNQSHGVEIVDALSAAVLDVDVVYDNYEPSNLSLFDHVFGFFSGVRQRGLQTTEEVLREGSFLTAIGELELDGDTLRMQPSNEGPLFLTTATKSTLIKRFEDAKTTTILKLVVCSTISAILVAFIAKKLYRKRKQEREEAKIRERLDTERRERRARSRPHTLSQDQLCVVCSTNPKEIILLPCGHVCLCEDCAQKISVTCPVCRGSIVSKAAAFIA","proteome":"UP000000803","gene":"Mul1","go_terms":[{"identifier":"GO:0004842","name":"ubiquitin-protein transferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006996","name":"organelle organization","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016567","name":"protein ubiquitination","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a84e93f49512c114eb8ddce91d191fd91725f2e5","counters":{"domain_architectures":2692,"entries":12,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":2,"cdd":1,"smart":1,"profile":1,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":2692}}}