{"metadata":{"accession":"Q9SJI9","id":"PCO4_ARATH","source_organism":{"taxId":"3702","scientificName":"Arabidopsis thaliana","fullName":"Arabidopsis thaliana (Mouse-ear cress)"},"name":"Plant cysteine oxidase 4","description":["Catalyzes the oxidation of N-terminal cysteine residues (N-Cys), thus preparing the protein for N-end rule pathway-mediated proteasomal degradation, upstream of the N-end rule enzymes ATE1, ATE2 and PRT6 (Probable) (PubMed:28332493, PubMed:29848548, PubMed:32868422, PubMed:33207269). Controls the preparation of the group VII ethylene response factor (ERF-VII) proteins for degradation via the 26S proteasome N-end rule pathway (Probable) (PubMed:28332493, PubMed:29848548, PubMed:32868422, PubMed:33207269). Acts as an oxygen sensor that controls the stability of ERF-VII proteins, which are stabilized in flooding-induced hypoxia, and regulate transcriptional adaptation to these adverse conditions (PubMed:28332493, PubMed:29848548)"],"length":241,"sequence":"MPYFAQRLYNTCKASFSSDGPITEDALEKVRNVLEKIKPSDVGIEQDAQLARSRSGPLNERNGSNQSPPAIKYLHLHECDSFSIGIFCMPPSSMIPLHNHPGMTVLSKLVYGSMHVKSYDWLEPQLTEPEDPSQARPAKLVKDTEMTAQSPVTTLYPKSGGNIHCFKAITHCAILDILAPPYSSEHDRHCTYFRKSRREDLPGELEVDGEVVTDVTWLEEFQPPDDFVIRRIPYRGPVIRT","proteome":"UP000006548","gene":"PCO4","go_terms":[{"identifier":"GO:0016702","name":"oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d4b7758babc4823e93df4117bf6fd436c4ddfa66","counters":{"domain_architectures":5758,"entries":8,"isoforms":2,"proteomes":1,"sets":2,"structures":3,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"cdd":1,"panther":1,"pfam":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":5758}}}