{"metadata":{"accession":"Q9P0R6","id":"GSKIP_HUMAN","source_organism":{"taxId":"9606","scientificName":"Homo sapiens","fullName":"Homo sapiens (Human)"},"name":"GSK3B-interacting protein","description":["A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:16981698, PubMed:25920809, PubMed:27484798). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:16981698, PubMed:27484798). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702)"],"length":139,"sequence":"METDCNPMELSSMSGFEEGSELNGFEGTDMKDMRLEAEAVVNDVLFAVNNMFVSKSLRCADDVAYINVETKERNRYCLELTEAGLKVVGYAFDQVDDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS","proteome":"UP000005640","gene":"GSKIP","go_terms":[{"identifier":"GO:0060828","name":"regulation of canonical Wnt signaling pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d08b35a3e0df172eac1ffa2d0635c514584092be","counters":{"domain_architectures":2148,"entries":7,"isoforms":0,"proteomes":1,"sets":0,"structures":1,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"pfam":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":2148}}}