{"metadata":{"accession":"Q9NZ52","id":"GGA3_HUMAN","source_organism":{"taxId":"9606","scientificName":"Homo sapiens","fullName":"Homo sapiens (Human)"},"name":"ADP-ribosylation factor-binding protein GGA3","description":["Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity)"],"length":723,"sequence":"MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEALQALTVLEACMKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLYSWTMALPEEAKIKDAYHMLKRQGIVQSDPPIPVDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLKSKNPDDLQEANKLIKSMVKEDEARIQKVTKRLHTLEEVNNNVRLLSEMLLHYSQEDSSDGDRELMKELFDQCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEGQVINGEVATLTLPDSEGNSQCSNQGTLIDLAELDTTNSLSSVLAPAPTPPSSGIPILPPPPQASGPPRSRSSSQAEATLGPSSTSNALSWLDEELLCLGLADPAPNVPPKESAGNSQWHLLQREQSDLDFFSPRPGTAACGASDAPLLQPSAPSSSSSQAPLPPPFPAPVVPASVPAPSAGSSLFSTGVAPALAPKVEPAVPGHHGLALGNSALHHLDALDQLLEEAKVTSGLVKPTTSPLIPTTTPARPLLPFSTGPGSPLFQPLSFQSQGSPPKGPELSLASIHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPLKEKVRLRYKLTFALGEQLSTEVGEVDQFPPVEQWGNL","proteome":"UP000005640","gene":"GGA3","go_terms":[{"identifier":"GO:0035091","name":"phosphatidylinositol binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043130","name":"ubiquitin binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006886","name":"intracellular protein transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016192","name":"vesicle-mediated transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0031267","name":"small GTPase binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005802","name":"trans-Golgi network","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c62f35af203683f8befa681abc6ccb25169bab59","counters":{"domain_architectures":4557,"entries":30,"isoforms":4,"proteomes":1,"sets":4,"structures":6,"taxa":1,"dbEntries":{"cathgene3d":4,"pfam":4,"cdd":2,"ssf":3,"smart":2,"profile":3,"panther":1,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":4557}}}