{"metadata":{"accession":"Q9NXA8","id":"SIR5_HUMAN","source_organism":{"taxId":"9606","scientificName":"Homo sapiens","fullName":"Homo sapiens (Human)"},"name":"NAD-dependent protein deacylase sirtuin-5, mitochondrial","description":["NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX"],"length":310,"sequence":"MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS","proteome":"UP000005640","gene":"SIRT5","go_terms":[{"identifier":"GO:0036054","name":"protein-malonyllysine demalonylase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0036055","name":"protein-succinyllysine desuccinylase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0070403","name":"NAD+ binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d025c4a47877c4dc4d451880aa4615a59586b83c","counters":{"domain_architectures":50198,"entries":14,"isoforms":4,"proteomes":1,"sets":2,"structures":26,"taxa":1,"dbEntries":{"profile":1,"ssf":1,"cathgene3d":2,"cdd":1,"panther":1,"hamap":1,"pfam":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":50198}}}