{"metadata":{"accession":"Q9M531","id":"H2A_EUPES","source_organism":{"taxId":"3993","scientificName":"Euphorbia esula","fullName":"Euphorbia esula (Leafy spurge)"},"name":"Histone H2A","description":["Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling"],"length":153,"sequence":"MDTGAKLKKGAGERKGGGPKKKPVSRSVKAGLQFPVGRIGRFLKKGRYAQRVGSGAPVYLAAVLEYLAAEVLELAGNAARDNKKNRIIPRHVLLAVRNDEELGKLLAGVTIAHGGVLPNINPVLLPKKAEKAAAAATKEPKSPAKATKSPKKA","proteome":null,"gene":null,"go_terms":[{"identifier":"GO:0046982","name":"protein heterodimerization activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030527","name":"structural constituent of chromatin","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000786","name":"nucleosome","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"de63b9b1b29a88c0202d646316133c44fdb4ad35","counters":{"domain_architectures":25209,"entries":15,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"smart":1,"ssf":1,"pfam":2,"cdd":1,"panther":1,"prosite":1,"prints":1,"interpro":6},"proteome":0,"taxonomy":1,"similar_proteins":25209}}}