{"metadata":{"accession":"Q9LFP6","id":"PIN8_ARATH","source_organism":{"taxId":"3702","scientificName":"Arabidopsis thaliana","fullName":"Arabidopsis thaliana (Mouse-ear cress)"},"name":"Auxin efflux carrier component 8","description":["Acts as a component of the auxin efflux carrier (PubMed:35768502). Component of the intracellular auxin-transport pathway in the male gametophyte (PubMed:20439545, PubMed:22540348). Involved in the regulation of auxin homeostasis in pollen (PubMed:22540348). Involved in the efflux of auxin from the endoplasmic reticulum into the cytoplasm (PubMed:22760640). Binds auxins including indole-3-acetic acid (IAA), naphthaleneacetic acid (NAA) and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), but barely indole-3-butyric acid (IBA) and 2-phenylacetic acid (PAA) (PubMed:35768502). PIN5 and PIN8 may have an antagonistic/compensatory activity (PubMed:22760640, PubMed:22990451). Involved in the control of vein patterning (PubMed:23437008, PubMed:24304505). Redundantly with PIN6, inhibits the vein-formation-promoting functions of PIN5 (PubMed:26560462). PIN5, PIN6, and PIN8 control vein network geometry, but they are expressed in mutually exclusive domains of leaf vascular cells (PubMed:26560462)"],"length":367,"sequence":"MISWLDIYHVVSATVPLYVSMTLGFLSARHLKLFSPEQCAGINKFVAKFSIPLLSFQIISENNPFKMSPKLILSDILQKFLVVVVLAMVLRFWHPTGGRGGKLGWVITGLSISVLPNTLILGMPILSAIYGDEAASILEQIVVLQSLIWYTILLFLFELNAARALPSSGASLEHTGNDQEEANIEDEPKEEEDEEEVAIVRTRSVGTMKILLKAWRKLIINPNTYATLIGIIWATLHFRLGWNLPEMIDKSIHLLSDGGLGMAMFSLGLFMASQSSIIACGTKMAIITMLLKFVLGPALMIASAYCIRLKSTLFKVAILQAALPQGVVPFVFAKEYNLHPEIISTGVIFGMLIALPTTLAYYFLLDL","proteome":"UP000006548","gene":"PIN8","go_terms":[{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"980782e3b76b22c6079e569e99daf39f1edf26fd","counters":{"domain_architectures":40792,"entries":6,"isoforms":0,"proteomes":1,"sets":1,"structures":7,"taxa":1,"dbEntries":{"ncbifam":1,"panther":1,"pfam":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":40792}}}