{"metadata":{"accession":"Q9JJL3","id":"SO1B2_MOUSE","source_organism":{"taxId":"10090","scientificName":"Mus musculus","fullName":"Mus musculus (Mouse)"},"name":"Solute carrier organic anion transporter family member 1B2","description":["Mediates the Na(+)-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates (estrone 3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate). Also transports prostaglandin E2 and L-thyroxine (T4). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions"],"length":689,"sequence":"MDQTQHPSKAAQPLRSEKTRHCDGFRIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGSILTALPHFFMGYYRYATENDISSLHNSTLTCLVNQTTSLTGTSPEIMEKGCEKGSNSYTWIYVLMGNMLRGIGETPIVPLGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGLLCIICSIPFFFLPKIPKRSQKERKNSASLHVLKTDEDKNPVTNPTTQEKQAPANLTGFLWSLRSILTNEQYVIFLILTLLQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLICENKAFAGLTLTYDGMNPVDSHIDVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKLMNIEFYDCSCVSGSGFQKGNHSARLGECPRDKCKTKYYFYITFQVIISFFTALGSTSLMLILIRSVQPELKSLGMGFHSLVVRTLGGILAPVYYGALIDRTCMKWSVTSCGARGACRLYNSRLFGMIYVGLSIALKTPILLLYVALIYVMKRKMKRNDNKILENGRKFTDEGNPEPVNNNGYSCVPSDEKNSETPL","proteome":"UP000000589","gene":"Slco1b2","go_terms":[{"identifier":"GO:0022857","name":"transmembrane transporter activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"9921360838b092afbbe83d58c42b78e1a41b29a1","counters":{"domain_architectures":11062,"entries":16,"isoforms":2,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cathgene3d":2,"profile":2,"pfam":2,"smart":1,"panther":1,"ncbifam":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":11062}}}