{"metadata":{"accession":"Q9JH58","id":"Q9JH58_HASV4","source_organism":{"taxId":"35300","scientificName":"Human astrovirus-4","fullName":"Human astrovirus-4 (HAstV-4)"},"name":"Capsid polyprotein VP90","description":["[Capsid polyprotein VP70]: The immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. During maturation, VP70 undergoes a loss of 60 peripentonal spikes, which likely plays an important role in viral infectivity","[Capsid polyprotein VP90]: The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the immature VP70 virion","[Core protein VP34]: Self-assembles to form an icosahedral capsid with a T=3 symmetry, about 43 nm in diameter. This forms contains only 30 spikes located on the icosahedral 2-fold axes","[Spike protein VP25]: VP25 and VP27 Forms the spikes at the surface of the virion. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis","[Spike protein VP27]: VP25 and VP27 Forms the spikes at the surface of the virion. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis"],"length":771,"sequence":"MASKSDKQVTVEVNNNGRSRSKSRARSQSRGRGRSVKITVNSNNKGRRQNGRNKYQSNQRVRKIVNKQLRKQGVTGPKPAICQTATATLGTIGSNTTGATEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVRLTSMVGASAVNGTVVRISLNPTSTPSSTSWSGLGARKHLDVTVGKNAVFKLKPSDLGGPRDGWWLTNTNDNASDTLGPSIEIHTLGQTMSSYQNTQFTGGLFLVELSSAWCFTGYAANPNLVNLVKSTDKSVDVTFEGSAGTPLIMNVPEHSHFARMAVEHSSLSTSLSRAGGESSSDTVWQVLNTAVSAAELVTPPPFNWLSKGGWWFVKLIAGRARTGARRFYVYPSYQDALSNKPALCTGGVSAYTRQSNPVRTTLQFTQMNQPSLGHGATPATLGRSIPEPGDQFKVIMTVGALVQPNRSDTQNWLFKTVTPPTGHDAARVGWNTQHYLTIQGFLLIDSLEWLTPNLQESQEPPSIPELGVYIGIHKKALVYFMQQYVNPHTNNKHQVSSIFLIKPTENFSVTSYMSYFFRESQSDQNVANLKIRPQTWQQTVNFQRGKWYLVTNTAIRNGPPPSGWVWDNIELTNESIYYADQVLAHFINPPPQNSKIYFEVHTTMPQSSARSIGLEEDQTDNWQEPDEDLQTSTEESDYETDSLEDESDDEDSNTCRELVINTLVNQGISRERATYIGMSAYPNVEWGSGEQSTSQHIQEISSDDVGAGAHYSCVCERKQQSLNQGSRGHAE","proteome":null,"gene":null,"go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"983e5a4fdafef0ef1315c174827562aa7a5a5b4a","counters":{"domain_architectures":245,"entries":6,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"cathgene3d":1,"interpro":3},"proteome":0,"taxonomy":1,"similar_proteins":245}}}