{"metadata":{"accession":"Q9FK25","id":"OMT1_ARATH","source_organism":{"taxId":"3702","scientificName":"Arabidopsis thaliana","fullName":"Arabidopsis thaliana (Mouse-ear cress)"},"name":"Flavone 3'-O-methyltransferase 1","description":["Methylates OH residues of flavonoid compounds. Converts quercetin into isorhamnetin. Dihydroquercetin is not a substrate. Catalyzes the methylation of monolignols, the lignin precursors. Does not contribute to the phenylpropanoid pattern of the pollen tryphine, but is probably confined to isorhamnetin glycoside biosynthesis (PubMed:10700397, PubMed:12777055, PubMed:20652169, PubMed:22258746). Involved in melatonin biosynthesis (PubMed:25039887, PubMed:25250906, PubMed:32354877). Functions as an acetylserotonin O-methyltransferase that catalyzes the transfer of a methyl group onto N-acetylserotonin (NAS), producing melatonin (N-acetyl-5-methoxytryptamine) (PubMed:25039887, PubMed:25250906). Can also methylate serotonin into 5-methoxytryptamine (5-MT) with low catalytic activity (PubMed:25250906). Implicated in melatonin-dependent circadian dynamics of stomatal aperture to minimize night water loss and promote drought tolerance (PubMed:32064655). Prevents the accumulation of oil and anthocyanin content in mature seeds, as well as mucilage production in the seed coat, in a melatonin-dependent manner (PubMed:32354877)"],"length":363,"sequence":"MGSTAETQLTPVQVTDDEAALFAMQLASASVLPMALKSALELDLLEIMAKNGSPMSPTEIASKLPTKNPEAPVMLDRILRLLTSYSVLTCSNRKLSGDGVERIYGLGPVCKYLTKNEDGVSIAALCLMNQDKVLMESWYHLKDAILDGGIPFNKAYGMSAFEYHGTDPRFNKVFNNGMSNHSTITMKKILETYKGFEGLTSLVDVGGGIGATLKMIVSKYPNLKGINFDLPHVIEDAPSHPGIEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCVKFLKNCYESLPEDGKVILAECILPETPDSSLSTKQVVHVDCIMLAHNPGGKERTEKEFEALAKASGFKGIKVVCDAFGVNLIELLKKL","proteome":"UP000006548","gene":"OMT1","go_terms":[{"identifier":"GO:0046983","name":"protein dimerization activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008168","name":"methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008171","name":"O-methyltransferase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"bdc835ccb83003619dd55371e507d9b3256eafa8","counters":{"domain_architectures":30676,"entries":16,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"pfam":2,"profile":1,"cdd":1,"pirsf":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":30676}}}