{"metadata":{"accession":"Q91YN5","id":"UAP1_MOUSE","source_organism":{"taxId":"10090","scientificName":"Mus musculus","fullName":"Mus musculus (Mouse)"},"name":"UDP-N-acetylhexosamine pyrophosphorylase","description":["Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (By similarity). Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) (By similarity). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection (PubMed:36603579). Regulates innate immunity by catalyzing pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses (By similarity)","Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P)","Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P)"],"length":522,"sequence":"MNVNDLKQRLSQAGQEHLLQFWNELSEAQQVELYMELQAMNFEELNSFFRKAIGEFDRSSHQEKVDARMEPVPRQVLGSATRDQEQLQAWESEGLSQISQNKVAVLLLAGGQGTRLGVSYPKGMYDVGLPSHKTLFQIQAERILKLQQLAEKHHGNKCTIPWYIMTSGRTMESTKEFFTKHKFFGLKKENVVFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGICSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQRRSSDGRLLFNAGNIANHFFTVPFLKDVVNVYEPQLQHHVAQKKIPYVDSQGYFIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSEAITADVNHNLKDANDVPIQCEISPLISYAGEGLEGYVADKEFHAPLIIDENGVHELVKNGI","proteome":"UP000000589","gene":"Uap1","go_terms":[{"identifier":"GO:0070569","name":"uridylyltransferase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"94e198e955f2cd10d0ca87ed10c772ebcbe0d255","counters":{"domain_architectures":17346,"entries":9,"isoforms":3,"proteomes":1,"sets":2,"structures":1,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":1,"cdd":1,"panther":1,"pfam":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":17346}}}