{"metadata":{"accession":"Q90ZE4","id":"PSN2_DANRE","source_organism":{"taxId":"7955","scientificName":"Danio rerio","fullName":"Danio rerio (Zebrafish)"},"name":"Presenilin-2","description":["Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (By similarity). May play a more prominent role in Notch signaling (PubMed:19563801)"],"length":441,"sequence":"MNTSDSEEDSYNERSALVQSESPTVPSYNQDNAMSLPQDTDSKRSGAVRSRSASGSGDAGPVDRERADTPDGEEEELTLKYGAKHVIMLFIPVTLCMVVVVATIKSVSFYTEKSGQRLIYTPFEEDPNSVGQRLLNSVLNTLVMISVIVFMTIILVLLYKYRCYKFIHGWLILSSLMLLFWFSFMYLGEVFKTYNVAMDYPTLLMIIWNFGVVGMICIHWKGPLRLQQAYLIVISALMALIFIKYLPEWSAWVILGAISIYDLIAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWMVGMADSNNPDSAGERRRSGGGVRTQEGVESEHDAPQAGRRQYSAEEDLEEDRGVKLGLGDFIFYSVLVGKAAATGGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFSTDNLVRPFMDSLAAHQYYI","proteome":"UP000000437","gene":"psen2","go_terms":[{"identifier":"GO:0042500","name":"aspartic endopeptidase activity, intramembrane cleaving","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0016485","name":"protein processing","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"08a79b6bf61fe701e9de73d7b1fa8e71bf2e01ee","counters":{"domain_architectures":1175,"entries":8,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"smart":1,"cathgene3d":1,"panther":1,"pfam":1,"prints":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":1175}}}