{"metadata":{"accession":"Q8ZKQ5","id":"LSRR_SALTY","source_organism":{"taxId":"99287","scientificName":"Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)","fullName":"Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)"},"name":"Transcriptional regulator LsrR","description":["Transcriptional regulator that represses the expression of the lsr operon (lsrACDBFGE) in the absence of the quorum-sensing signaling molecule autoinducer 2 (AI-2) (PubMed:11722742, PubMed:14622426, PubMed:20628367). It also represses the expression of the lsrRK operon (PubMed:20628367). Acts by binding to the intergenic region between the lsr operon and lsrR (PubMed:20628367). In the presence of phosphorylated autoinducer-2 (phospho-AI-2), LsrR is inactivated, leading to the transcription of the genes (PubMed:14622426). The regulatory function of LsrR was thought to be limited to the lsr operon, but it was subsequently shown to be involved, directly or indirectly, in the regulation of SPI-1 and flagella genes (PubMed:22623980). It negatively regulates the expression of those genes, which reduces the ability of Salmonella to invade host cells (PubMed:22623980)"],"length":319,"sequence":"MSDNTLVSDYGMCEEEQVARIAWFYYHDGLTQSEISERLGLTRLKVSRLLEKGHQSGIIRVQINSRFEGCLEYENALRNHFALQNIRVLPALPDADIGLRLGIGAAHMLMESLRPQQLLAVGFGEATMTTLKRLSGFISAQQIRLVTLSGGVGPYMTGIGQLDAACSVSIMPAPLRASSQEIACTLRNENSVRDVMLTAQAADAAIVGIGAINQKDQASILKSGYITQGEQLMIGRKGAVGDILGYFFDAHGEIIPDIKIHNELIGLKLNSLSTIPTVIGVAGGEQKAEAIIAAMRGNYINALVTDQKTAGKIIQIIEK","proteome":"UP000001014","gene":"lsrR","go_terms":[{"identifier":"GO:0030246","name":"carbohydrate binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c033a5ff1ebc8c1860374ed4ac6407a1a9d3b582","counters":{"domain_architectures":10402,"entries":10,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"pfam":1,"ssf":1,"ncbifam":1,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":10402}}}