{"metadata":{"accession":"Q8VZG8","id":"MIK2_ARATH","source_organism":{"taxId":"3702","scientificName":"Arabidopsis thaliana","fullName":"Arabidopsis thaliana (Mouse-ear cress)"},"name":"MDIS1-interacting receptor like kinase 2","description":["Acts as a receptor of SCOOP peptides from Brassicaceae plants regulating multiple processing including plant growth, development and stress responses (PubMed:33514716, PubMed:34535661). Perception of SCOOP peptides induces the association of MIK2 with the coreceptors BAK1/SERK3 and SERK4 and relays the signaling through the activation of receptor-like cytosolic kinases (RLCKs) BIK1 and PBL1 (PubMed:33514716, PubMed:34535661). Also able to detect SCOOP-like proteins (SCOOPL) present in fungal Fusarium spp. and bacterial Comamonadaceae to elicit various immune responses, including growth inhibition, ROS production, calcium Ca(2+) influx, MAPK activation and MYB51 promoter activation in roots, thus being required for resistance to several root pathogens (PubMed:33514716, PubMed:34535661). Involved in the pollen tube perception of the female signal (PubMed:26863186). Required to trigger defense responses toward generalist herbivores such as Spodoptera littoralis, probably via the activation of jasmonate and indole glucosinolate biosynthesis (PubMed:35401621)"],"length":1045,"sequence":"MNKTNPERKISLTSFKERMACKEKPRDLQVLLIISIVLSCSFAVSATVEEANALLKWKSTFTNQTSSSKLSSWVNPNTSSFCTSWYGVACSLGSIIRLNLTNTGIEGTFEDFPFSSLPNLTFVDLSMNRFSGTISPLWGRFSKLEYFDLSINQLVGEIPPELGDLSNLDTLHLVENKLNGSIPSEIGRLTKVTEIAIYDNLLTGPIPSSFGNLTKLVNLYLFINSLSGSIPSEIGNLPNLRELCLDRNNLTGKIPSSFGNLKNVTLLNMFENQLSGEIPPEIGNMTALDTLSLHTNKLTGPIPSTLGNIKTLAVLHLYLNQLNGSIPPELGEMESMIDLEISENKLTGPVPDSFGKLTALEWLFLRDNQLSGPIPPGIANSTELTVLQLDTNNFTGFLPDTICRGGKLENLTLDDNHFEGPVPKSLRDCKSLIRVRFKGNSFSGDISEAFGVYPTLNFIDLSNNNFHGQLSANWEQSQKLVAFILSNNSITGAIPPEIWNMTQLSQLDLSSNRITGELPESISNINRISKLQLNGNRLSGKIPSGIRLLTNLEYLDLSSNRFSSEIPPTLNNLPRLYYMNLSRNDLDQTIPEGLTKLSQLQMLDLSYNQLDGEISSQFRSLQNLERLDLSHNNLSGQIPPSFKDMLALTHVDVSHNNLQGPIPDNAAFRNAPPDAFEGNKDLCGSVNTTQGLKPCSITSSKKSHKDRNLIIYILVPIIGAIIILSVCAGIFICFRKRTKQIEEHTDSESGGETLSIFSFDGKVRYQEIIKATGEFDPKYLIGTGGHGKVYKAKLPNAIMAVKKLNETTDSSISNPSTKQEFLNEIRALTEIRHRNVVKLFGFCSHRRNTFLVYEYMERGSLRKVLENDDEAKKLDWGKRINVVKGVAHALSYMHHDRSPAIVHRDISSGNILLGEDYEAKISDFGTAKLLKPDSSNWSAVAGTYGYVAPELAYAMKVTEKCDVYSFGVLTLEVIKGEHPGDLVSTLSSSPPDATLSLKSISDHRLPEPTPEIKEEVLEILKVALLCLHSDPQARPTMLSISTAFS","proteome":"UP000006548","gene":"MIK2","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"785741de275a5c09a90d79f05720f11776d2f864","counters":{"domain_architectures":29,"entries":29,"isoforms":2,"proteomes":1,"sets":2,"structures":5,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":3,"pfam":5,"smart":2,"profile":2,"panther":1,"prints":1,"prosite":2,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":29}}}