{"metadata":{"accession":"Q8I6Z7","id":"PDEB_PLAF7","source_organism":{"taxId":"36329","scientificName":"Plasmodium falciparum (isolate 3D7)","fullName":"Plasmodium falciparum (isolate 3D7)"},"name":"Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase beta","description":["Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:30794532). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:30794532). By regulating cAMP levels during the asexual blood stage and, thus PKA activation, required for merozoite invasion of erythrocytes and for the parasite development immediately following invasion (PubMed:30794532)"],"length":1139,"sequence":"MGKVEDFEEHNKNSNQDIEKNVGNRRRSNSNTINDQNENINKNKAIVTKKSFIMNLLRNKEKTKVEQNDDNIVENMNERKNSLKDMSLISDNVEKDNKVKKKNSYLKNLNILGKTKSIEFSFPSNILNNARKNIQEIDEESPLTSNSLRTYKEGISEDNRQNQRNADNNSLNWSTSNINTECNSEFSNIEVKVLKTEKSNSVKLKDNIIDIPNDKNKKELQEINIKNTNKDSYKNLYLKVRNSISFNDNIKIDDENKNDKNNIIDNYNNYDDINSSNEITIDGLNHDDNIKKIDNINNFDNKHDDNLQDHHQNHVHHTFRSSRKSLGNIKSNNTNIKLNNDKNFDTNINKRSILEKYFYDIWKRNITIKKEIYSLSSKNPPNPLKSTFADACQNESSEKELLKKIPLKFNDDSIESLYVLNLNNWISSRMIIIGIVMLILSFIIWPLTTWSLKTSTWGRETYIIILFHTLMAINTLILIFFIIIGSTELCKYSECMSYVLFSLMVALWGLWNIAIGLTLEYNPNLSEMPTTTYELEMIYVLTYIYGFLPLVIIDIFFPSRTKYNWIIHLIFIFLNSSSIILVGSAKPDFVPEIYVVFRILAYTTLCIFLYIGSYTSELQIRYVFYNLLVAGYKLDKIESDMKNKTSNKKISTGIEDLINMLKECTKVILELENETDTNFNVHTKTSYCSNILEQCLSTLTKSDNLYNIDYNVLENPENKKFIEAYVSKSKSNFAGEEVPKGVDFKLNKSFSNNDCISTDKVDLDKKQIKKFLKQINISQLTKMIQFIDNKLLSDWDFNCLTYFDESEYPFFDINLSLICTIDHNIPINIIINFLCFVEKQYNNVPYHNTIHATMVTQKFFCLAKKLGIYDDLEYKIKLVMFISGICHDIGHPGYNNLFFVNSLHPLSIIYNDISVLENYHASITFKILQLNQCNILKNFSEKDFRMMRSYIIELILSTDMKHHFEIISKFRIRRENEDFDYIKNSDDLLILTKMIIKSADISHGSVSWSEHYCWCQRVLSEFYTQGDEELKNKMPLSPLCDRTKHNEVCKSQITFLKFVVMPLFEELSHIDNNKFIKSFCLKRLNSNCIMWDTLMKEEKTIEVYDPAAVKLKDKKKKKVDKKKKSYIDLTLFFIKNVSD","proteome":"UP000001450","gene":"PDEbeta","go_terms":[{"identifier":"GO:0004114","name":"3',5'-cyclic-nucleotide phosphodiesterase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008081","name":"phosphoric diester hydrolase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"55c76fe585d3fb9c71ce12a59464e90a49687b13","counters":{"domain_architectures":20360,"entries":14,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":1,"ssf":1,"cathgene3d":1,"smart":1,"cdd":1,"pfam":1,"panther":1,"prosite":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":20360}}}