{"metadata":{"accession":"Q8HXX6","id":"SAP3_MACFA","source_organism":{"taxId":"9541","scientificName":"Macaca fascicularis","fullName":"Macaca fascicularis (Crab-eating macaque)"},"name":"Ganglioside GM2 activator","description":["Lipid-binding and transfer protein essential for lysosomal degradation of ganglioside GM2. Extracts single GM2 molecules from intralysosomal luminal vesicle (ILV) membranes and presents them in soluble form to beta-hexosaminidase A (HEXA) for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Forms a stoichiometric GM2-GM2A complex that serves as the substrate for HEXA (By similarity). Also stimulates the breakdown of glycolipid GA2 by HEXA (By similarity). Possesses dual function: membrane lipid mobilization/solubilization and lipid substrate presentation to hydrolases (By similarity). The large binding pocket can accommodate several single-chain phospholipids and fatty acids. Exhibits some calcium-independent phospholipase activity (By similarity). Participates in cholesterol transfer (By similarity)"],"length":190,"sequence":"MQSLMQAPVLIALGLLFAAPAQAHLKKLGSFSWDNCDEGKDPAVIRSLTLEPDPILIPGNVTVSVVGSTSVLLSSPLKVELVLEKEVAGLWIKIPCTDYIGSCTFEDFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPHLELPSWLTTGNYRIESILSNRGKRLGCIKIAASLKGV","proteome":"UP000233100","gene":"GM2A","go_terms":[{"identifier":"GO:0008047","name":"enzyme activator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006689","name":"ganglioside catabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"f987f23ac86eaabd183ac60f083a5628166b7889","counters":{"domain_architectures":10826,"entries":8,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":1,"ssf":1,"smart":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":10826}}}