{"metadata":{"accession":"Q869N9","id":"IF2A_DICDI","source_organism":{"taxId":"44689","scientificName":"Dictyostelium discoideum","fullName":"Dictyostelium discoideum (Social amoeba)"},"name":"Eukaryotic translation initiation factor 2 subunit 1","description":["eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B"],"length":341,"sequence":"MVFENDCRMYEKKYPEENELVMVRIESIGDMGVYVSLLEYNNIEGMILLSEISRRRIRSINKLVRVGKTEAVVVVRVDKDKGYIDLSKRRVTPEEYAQCEERFHKSKAVHGIVRYVATKLSTEDNVVKTKHLYTKFVWPLYTKYGHAYEAFKLSITEPSVFNGFDIAENERKVLMETIIQKLKPQPHKVRADLEITCYDYEGIDAIKHAITASQNHALSVLKAPEDGKFDEKAFGVVTIKLVAPPLYVMVGTFDEKEKGLSMVGQCVDVLSEEITKKNGNLTIKAAPRIVGAVDDQELRDLMEQLEVENQDGDGEEHEDDDDDDDDEEEEEKPKEKKSSRK","proteome":"UP000002195","gene":"eif2s1","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003743","name":"translation initiation factor activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"2fb0ece446404da3daad65fe781defa909f63834","counters":{"domain_architectures":5423,"entries":18,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":3,"pfam":2,"cdd":1,"smart":1,"profile":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":5423}}}