{"metadata":{"accession":"Q7ZUU9","id":"Q7ZUU9_DANRE","source_organism":{"taxId":"7955","scientificName":"Danio rerio","fullName":"Danio rerio (Zebrafish)"},"name":"Retinoblastoma-binding protein 5","description":["In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B"],"length":512,"sequence":"MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLSWSRDGHKLVSASTDNIVSQWDVLTGDCDQRFRFPSPILKLQYHPRDMNKVLVCPMKSAPVLLTLSDSKHVVLPVDDDSDLNVVAAFDRRGEYIYTGNAKGKILVLNTDTQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKRCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIPAFCSSDEELEDYKALLYLPIAPEVEDPEENPFGPPPDATAQNASTDDGSAHTGPGDKKRHPSADGAPPKKKIRTTTIELQGVPSDEVHPLLGVKGDSKSKKKAAGRPKGSKGNLVAAVYKQHEVQGLD","proteome":"UP000000437","gene":"rbbp5","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0048188","name":"Set1C/COMPASS complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":1,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"35c3a2b802fd9ab75d4e0df5220beffd6dca46af","counters":{"domain_architectures":93161,"entries":10,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"smart":1,"cathgene3d":1,"pfam":1,"profile":2,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":93161}}}