{"metadata":{"accession":"Q7SY74","id":"Q7SY74_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"Elongation of very long chain fatty acids protein 1","description":["Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators"],"length":290,"sequence":"MEAILSEWVQKYHDFMKGADPRIYDYPLMQSPFLPGAILLGYVYFVLSLGPRIMANRKPFDLKPLMVVYNFSLVALSAYIVYEFLMSGWLTGYTWRCDPVDVSDKPMALRMVQVAWLFLFSKFIELLDTVFFVVRKKNSQITFLHIIHHSVLPWSWWWGVKFGPGGMGSFHAMINSLVHVIMYFYYGLSAAGPRFQKYLWWKKHMTAIQLIQFVLVSIHISQYYFMPSCDYQFPIFIHLIWIYGTVFFILFSNFWYQAYTKGRRLPKGSTVANGALHRNGKAKNGKYKEN","proteome":"UP000186698","gene":"elovl1.L","go_terms":[{"identifier":"GO:0009922","name":"fatty acid elongase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019367","name":"fatty acid elongation, saturated fatty acid","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0042761","name":"very long-chain fatty acid biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005783","name":"endoplasmic reticulum","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"726b44df556ad17af08cf1eeb76a7efce6e198bf","counters":{"domain_architectures":25966,"entries":5,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"hamap":1,"panther":1,"pfam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":25966}}}