{"metadata":{"accession":"Q6PFH3","id":"DCA15_MOUSE","source_organism":{"taxId":"10090","scientificName":"Mus musculus","fullName":"Mus musculus (Mouse)"},"name":"DDB1- and CUL4-associated factor 15","description":["Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins. The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3. May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells"],"length":600,"sequence":"MAPSSKSERNSGAGSAGGGPGGTGGKRAVGRRREHVLKQLERVKISGQLSPRLFRKLPPRVCVSLKNIVDEDFLYAGHIFLGFSKCGRYVLSYTSSSGDDDFSFYIYHLYWWEFNVHSKLKLVRQVRLFQDEEIYSDLYLTVCEWPSDASKVIVFGFNTRSANGMLMNMMMMSDENHRDIYISTVAVPPRGRCAACQDASRAHPGDPSAQCLRHGFMLHTKYQVVYPFPTFQPAFQLKKDQVVLLNTSYSLVACAVSVHSAGDSSFCQILYDHTALPPAPPSSPGPWSPEAAPAFPSLGVEVVPAQPSGAPEPSPAIAKAKEFVADIFRRAKEAKGSPLEETRLPSSLGPSSSRCRPSLEPQAPSGEVVPRDSPPAAETTAPEPGYINYTKLHYVLQSGEGTEPEDEFEDDKISLPFVVTDLRGRNLRPMRERTDMQGQYLTVEQLTLDFEYVINEVIRHDATWGHQFCSFSDYDIVILEVCPETNQVLINIGLLLLAFPAPTEEGQLRPKTYHTSLKVAWDLNTGIFETVSVGDLTEVKGQTSGSVWSSYRKSCVDMVMKWLVPESSGRYVNRMTNEALHKGCSLKVLADSERYTWIVL","proteome":"UP000000589","gene":"Dcaf15","go_terms":[{"identifier":"GO:0016567","name":"protein ubiquitination","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"9e07e9bef470d3af2910e87298803be89f195955","counters":{"domain_architectures":1063,"entries":7,"isoforms":2,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cdd":2,"pfam":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":1063}}}