{"metadata":{"accession":"Q6PB07","id":"Q6PB07_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"Flavin-containing monooxygenase","description":["Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects"],"length":537,"sequence":"MVKKICVVGAGSSGLAAIKCCLEEDLEPTCFERYHDIGGLWRYKEDPEEGRASIYKSVIINTSKEMMCFSDYPIPDDFPNYMHNSKIMDYFRMYAKNFNLLKYIRFKTTVCSIKKRPDFAISGQWEIVTECDGKQDMGIYDGVLLCSGHHTFPNLPLESFPGIEKFKGQYFHSREYKYPHSFQDKRIIVIGIGNSGGDLAVELSTVAQQVYLSTRRGAWVINRVHDEGYPLDVVLLSRFKNVIKEFMTTDMLNCWVEKRLNARFNHENFGLKPKHRILSQHPTINDDLPNRIISGKVIMKTNVKGFTETDAIFEDGTIEKNIDVVFFATGYSFSFPFFEDSVLNAENNKIPLYKFVFPPHLEKTTVACIGLIQPLGAIMPVSELQCRWAVRVFKGLAKLPSQEDMLADVACKKKEMECRYVTSPRHTIQVDYLDYMDELASQFGVKPNLLHFLFTDPILAWEMFFGPCTPYQYRLMGSNKWSGARKAILTQQERIIKPTKSRVLVDDDMKKHHSVIPFPLKLLAVFALLAAVYFICL","proteome":"UP000186698","gene":"fmo5.2.S","go_terms":[{"identifier":"GO:0050660","name":"flavin adenine dinucleotide binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0050661","name":"NADP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004499","name":"N,N-dimethylaniline monooxygenase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"cea59a56e6d7a75ef5681f4b224bfc6672b76e85","counters":{"domain_architectures":47203,"entries":12,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pirsf":1,"panther":1,"pfam":1,"prints":2,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":47203}}}