{"metadata":{"accession":"Q6NU03","id":"Q6NU03_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"AMSH-like protease","description":["Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex. Does not cleave 'Lys-48'-linked polyubiquitin chains"],"length":431,"sequence":"MEQPISVSSLKKLVAVPDHTDVSLSPDERVRVLSKLGCNITINEDITPRRYFRSGVEMERMASVYLEEGNLENAFVLYNKFITLFVEKLPGHRDYQQYEIPEKQDILTKLKEVAFPRTDVLKKDLLKKYNLEYQEYLQGIHKRKSECLKKLEQQQLIDAEKKRLAQLRQQQIETEQFSFFEDQLRKQDLIRDQLKNKDAPKVPEQIDGGMVTCISTTKSSSKEQAKRNDASIYTGQSPPVTRALKPAATLSAVQNEIVDGLRLVALPRDLSHRFLQLAEANTSRGIETCGILCGKLTHDEFTITHVIVPKQSAGPDYCDMENVEELFNVQDQHNLLTLGWIHTHPTQTAFLSSVDLHTHCSYQLMLPEAIAIVCSPKHNDTGIFRLTSAGMLEVSACKKKGFHPHSKEPRQFNTCRHVMVRDAGITVLDLR","proteome":"UP000186698","gene":"stambpl1.S","go_terms":[{"identifier":"GO:0061578","name":"K63-linked deubiquitinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0140492","name":"metal-dependent deubiquitinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016579","name":"protein deubiquitination","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0070536","name":"protein K63-linked deubiquitination","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008233","name":"peptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008237","name":"metallopeptidase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"b0d3c2234d921e15c4ac0f7103e62095a3f2230d","counters":{"domain_architectures":4918,"entries":14,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"pfam":2,"ssf":2,"cdd":1,"smart":1,"profile":1,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":4918}}}