{"metadata":{"accession":"Q6NS26","id":"CDKAL_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"Threonylcarbamoyladenosine tRNA methylthiotransferase","description":["Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine"],"length":556,"sequence":"MPAVCESLLDDIEDMVSATDPKPHDRQSARKNIVPRARKRNKNNIQEEEPPADSTIPGTQKIWIRTWGCSHNNSDGEYMAGQLAAYGYSITEQPEKADLWLLNSCTVKSPAEDHFRNSIKKAQEANKKVVVSGCVPQAQPRQDYMKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGELASYPVEELVDRATQSFQEGVCEIWLTSEDTGAYGRDIGTDLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMDMKREYCIADFKRVVDFLKERVPGITIATDIICGFPGETDEDFKETLKLVEEYKFPSLFINQFYPRPGTPAAKMEQVLAHVKKRRTKELSQLFHSYDPYDHKIGQKQQVLVTEESFDSQYYVAHNRFYEQVLVPKDPDFMGKMVEVKIFEAGKHFMKGQPVQDSYIYTPSITKPLAKGEVSGLTEELKPPNNIPKSETLLEKHWERLQVFLFLTALLAAVIAFVGTKLV","proteome":"UP000186698","gene":"cdkal1","go_terms":[{"identifier":"GO:0035596","name":"methylthiotransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051539","name":"4 iron, 4 sulfur cluster binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051536","name":"iron-sulfur cluster binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016740","name":"transferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006400","name":"tRNA modification","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035598","name":"tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0035600","name":"tRNA methylthiolation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"174dc51e9bfbb664d85de61124045069ab770994","counters":{"domain_architectures":21985,"entries":28,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"profile":3,"cathgene3d":2,"ssf":1,"smart":1,"pfam":3,"cdd":1,"panther":1,"sfld":3,"ncbifam":2,"prosite":1,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":21985}}}