{"metadata":{"accession":"Q6GL40","id":"Q6GL40_XENTR","source_organism":{"taxId":"8364","scientificName":"Xenopus tropicalis","fullName":"Xenopus tropicalis (Western clawed frog)"},"name":"NF-kappa-B inhibitor alpha","description":["Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription"],"length":315,"sequence":"MSVPFHDYQGNMMEGEARDLRKDKLLQDDRIDSGLDSLKEEEYTAIITDLSNMRMEGPPDTSNYEPEPWKKEVNEDGDTFLHLAIIHEEKTLVKEAIQRSYRDHFYLNKQNNLHQTALHLAVITEQQDISQSLLQAGCDPEIQDFCGNTALHIACKQGSLRGVGVIFQYCEKQLPALLQSVNYDGHTCLHLASIHGYLAIVENLINKGADINAQEPCNGRTVLHMAVDLQNYDLMKLLLKHGADVNRVTYQGYSPCQLTWGRNNMLIQQQLVEVTHKNLQYLPESEEEDSSDSEYEYNDDELMYDDCIIGGRPLH","proteome":"UP000008143","gene":"nfkbia","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"19028327281c6137a19c9e0fe43f5e35bbb621f2","counters":{"domain_architectures":42283,"entries":11,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":1,"smart":1,"ssf":1,"profile":2,"panther":1,"prints":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":42283}}}