{"metadata":{"accession":"Q5U7A7","id":"Q5U7A7_DANRE","source_organism":{"taxId":"7955","scientificName":"Danio rerio","fullName":"Danio rerio (Zebrafish)"},"name":"Exostosin-2","description":["Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling"],"length":719,"sequence":"MCASGKYGSRGPALIPRMKTKHRIYYITLFSVVLLGLIATGMFQFWPHSIESSAEWSLDRRSVHDAPLVRISVNSPIPGRGDLSCRMHTCFDVYRCGYNPKNKIKVYIYPLQRFVDEVGVPISSTGLSREYNDLLSAISDSDFYTDDVSRACLFVPSIDVLNQNSLRIRETAQALAMLPRWDKGMNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPERQPGPRRYFILSSQTAIHREYRVELERLKDENGEALLLLDKCSNLSQGLTSVRKRCYKGQVYDYPQILQESSFCVVLRGARLGQATLSDVLQAGCVPVIMADSYILPFSEVLDWKRASVVIPEEKLPEMYTILKSIPHRQVEEMQRQARWFWEAYFSSMKAIGMTTLQIINDRIYPYAAHTYEEWNNPPVVKWSSVNSPLFLPLIPPRSPGFTAVVLTYDRIESLFRVITEISKVPSLAKLLVVWNNQNKSPPEESLWPKVAVPLKVVRTKENKLSNRFFPFDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMGKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANITGKAPIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL","proteome":null,"gene":"ext2","go_terms":[{"identifier":"GO:0016757","name":"glycosyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0009101","name":"glycoprotein biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"44e238d23fe7f153f1e0e6683a77728f5dab92d7","counters":{"domain_architectures":5830,"entries":9,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"ssf":1,"cathgene3d":1,"panther":1,"interpro":4},"proteome":0,"taxonomy":1,"similar_proteins":5830}}}