{"metadata":{"accession":"Q5R7T1","id":"Q5R7T1_PONAB","source_organism":{"taxId":"9601","scientificName":"Pongo abelii","fullName":"Pongo abelii (Sumatran orangutan)"},"name":"Acyl-coenzyme A thioesterase 8","description":["Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). Is also able to hydrolyze CoA esters of dicarboxylic acids. It is involved in the metabolic regulation of peroxisome proliferation"],"length":281,"sequence":"MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKVPVLYQVERTRTGSSFLVRSVKAVQHGKPIFICQASFQQAQPSPMQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGEGDMKMHCCVAAYISDYAFLGTALLPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWAG","proteome":null,"gene":"DKFZp459N2124","go_terms":[{"identifier":"GO:0047617","name":"fatty acyl-CoA hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006637","name":"acyl-CoA metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fd1a9168905e51b62daba36d9e70782041295dfb","counters":{"domain_architectures":13240,"entries":13,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":2,"pfam":2,"panther":1,"ncbifam":1,"interpro":5},"proteome":0,"taxonomy":1,"similar_proteins":13240}}}