{"metadata":{"accession":"Q5H9Q6","id":"Q5H9Q6_HUMAN","source_organism":{"taxId":"9606","scientificName":"Homo sapiens","fullName":"Homo sapiens (Human)"},"name":"Inosine-5'-monophosphate dehydrogenase","description":["Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors"],"length":599,"sequence":"MEGPLTPPPLQGGGAAAVPEPGARQHPGHETAAQRYSARLLQAGYEPESCFLLELSSVVLLAGVGVQMDRLRRASMADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSAASASRIPKQWYQRRVKKTCRQPRPLDT","proteome":null,"gene":"DKFZp781N0678","go_terms":[{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003938","name":"IMP dehydrogenase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006164","name":"purine nucleotide biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"9a01abf0d371224a404878e839c2974d8a828f12","counters":{"domain_architectures":30944,"entries":18,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"smart":2,"cdd":2,"pfam":2,"profile":1,"panther":1,"ncbifam":1,"hamap":1,"prosite":1,"interpro":5},"proteome":0,"taxonomy":1,"similar_proteins":30944}}}