{"metadata":{"accession":"Q57T48","id":"MTNN_SALCH","source_organism":{"taxId":"321314","scientificName":"Salmonella choleraesuis (strain SC-B67)","fullName":"Salmonella choleraesuis (strain SC-B67)"},"name":"5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase","description":["Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation"],"length":232,"sequence":"MKIGIIGAMEEEVTLLRDKIDNRQTITLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLASTLKVGDIVVSDETRYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAESCIRELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPDAVAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSTLMVETLVQKLAHG","proteome":null,"gene":"mtnN","go_terms":[{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009116","name":"nucleoside metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008782","name":"adenosylhomocysteine nucleosidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008930","name":"methylthioadenosine nucleosidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009164","name":"nucleoside catabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0019509","name":"L-methionine salvage from methylthioadenosine","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"27552274e8941821ae0d138350daef5fe3adde72","counters":{"domain_architectures":85785,"entries":11,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"pfam":1,"cdd":1,"panther":1,"ncbifam":2,"hamap":1,"interpro":3},"proteome":0,"taxonomy":1,"similar_proteins":85785}}}