{"metadata":{"accession":"Q55215","id":"DNRD_STRS5","source_organism":{"taxId":"45212","scientificName":"Streptomyces sp. (strain C5)","fullName":"Streptomyces sp. (strain C5)"},"name":"Aklanonic acid methyl ester cyclase DauD","description":["Involved in the biosynthesis of aklavinone which is an important precursor common to the formation of the clinically significant anthracyclines such as carminomycin, daunorubicin (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin). These compounds are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the cyclization of aklanonic acid methyl ester to yield aklaviketone"],"length":161,"sequence":"MSPQIDLVRRMVEAYNTGKTDDVAEFILHEYLNPGALEHNPELRGPEAFAAAVTWLKYAFSEEAHLEEIGYEENGPWVRAKLALYGRHVGNLVGMPATGRRFSGEQIHLIRIVDGKIRDHRDWPDYLGTYRQLGEPWPTPEGWRPCPPPPRRRHDRSTDTP","proteome":null,"gene":"dauD","go_terms":[{"identifier":"GO:0030638","name":"polyketide metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ce198cde16387ff32ac89cbf0229788e1ace81ea","counters":{"domain_architectures":16702,"entries":7,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"ncbifam":1,"panther":1,"interpro":2},"proteome":0,"taxonomy":1,"similar_proteins":16702}}}