{"metadata":{"accession":"Q50H33","id":"KCTD8_MOUSE","source_organism":{"taxId":"10090","scientificName":"Mus musculus","fullName":"Mus musculus (Mouse)"},"name":"BTB/POZ domain-containing protein KCTD8","description":["Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization"],"length":476,"sequence":"MALKDTGSGGSTILPISEMVSASSSPGAPLAAAPGPCAPSPFPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPRGGARRRGDLPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFPEKERLLREAEFFQLTDLVKLLSPKVTKQNSLNDECCQSDLEDNVSQGSSDALLLRGAAAGAPSGSGAHGVSGVVGGGSAPDKRSGFLTLGYRGSYTTVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRQPEKYTSRFYLKFTYLEQAFDRLSEAGFHMVACNSSGTAAFVNQYRDDKIWSSYTEYIFFRPPQKIVSPKQEHEDRKRDKVTDKGSESGTSCNELSTSSCDSHSEASTPQDNPANTQQAAAHQPNTLTLDRPSRKAPVQWMPPPDKRRNSELFQSLISKSRETNLSKKKVCEKLSVEEEMKKCIQDFKKIHIPDCFPERKRQWQSELLQKYGL","proteome":"UP000000589","gene":"Kctd8","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051260","name":"protein homooligomerization","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"2231b383d0e2bf7198f7bd33f04c55126c47242b","counters":{"domain_architectures":3358,"entries":13,"isoforms":2,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cdd":2,"cathgene3d":1,"ssf":1,"smart":1,"pfam":2,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":3358}}}