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{
    "metadata": {
        "accession": "Q3SYT1",
        "id": "DPH1_BOVIN",
        "source_organism": {
            "taxId": "9913",
            "scientificName": "Bos taurus",
            "fullName": "Bos taurus (Bovine)"
        },
        "name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1",
        "description": [
            "Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity)"
        ],
        "length": 438,
        "sequence": "MAALVAAEAAESCSRNGPGRGRAPRGRLANQIPAEILNNPQLQAAIQVLPSNYNFEVPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTEAEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLVPMDTSAQDFRVLYVFVDIRIDTAHLLDSIRLTFPPASALALVSTIQFVSTLQAAAQELKAEYRVSVPQCKPLSPGEILGCTSPCLPKEVEAVVYLGDGRFHLESVMIANPNISAYRYDPYSKVLSREHYDHQRMQANRQEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLQALGLPFVRLLLSEIFPSKLSLLPEVDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISWQQPYPMDFYASSSLGPWTVNHGRDRLLQVPGRLALGKVQGGPARPSPAAACEACSCRDEEVSPIAL",
        "proteome": "UP000009136",
        "gene": "DPH1",
        "go_terms": [
            {
                "identifier": "GO:0090560",
                "name": "2-(3-amino-3-carboxypropyl)histidine synthase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0017183",
                "name": "protein histidyl modification to diphthamide",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 2,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "ida_accession": "3a7bb4719785c490f9695451c41f9eb2b83c367f",
        "counters": {
            "domain_architectures": 7814,
            "entries": 11,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 0,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ncbifam": 1,
                "cathgene3d": 3,
                "panther": 1,
                "sfld": 1,
                "pfam": 1,
                "interpro": 4
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 7814
        }
    }
}