{"metadata":{"accession":"Q3MHI4","id":"PHAX_BOVIN","source_organism":{"taxId":"9913","scientificName":"Bos taurus","fullName":"Bos taurus (Bovine)"},"name":"Phosphorylated adapter RNA export protein","description":["A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA (By similarity)"],"length":394,"sequence":"MAQEAGDMDDGQVSDSDSDMTVAPSDRPLPVPKALGGDCGLRPFQSTATACAPASHYRTVKSVDSSEESFSDSDDDSSVWKRKRQKCFNTPPKPEPFQFDQSSQKPPIAGRKKVNNIWSAVLQEQNQDAVATELGILGMEGTIDRSRQSETYNYLLAKKLKRESQEHTKELDKELEEYMHGGKKTGPKEEENGQGHPKRKRPVKDRVGDRLEMNYKGRYEITEDDSQERVADEISFRLQEPKKDLIARVVRIIGNKKAIELLMETAEVEQNGGLFIMNGSRRRTPGGVFLNLLKNTPSISEEQIKDIFYLENQKEYENKKAARKRRIQVMGKKMKQAIKNLNFQEDDDTSRETFASDTNEALASLDESQEGHGETKLDAEEAIEVDHSHDLDMF","proteome":"UP000009136","gene":"PHAX","go_terms":[{"identifier":"GO:0006408","name":"snRNA export from nucleus","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c62a24f2a5048b3359bfb99cebb1bc2f65a149b4","counters":{"domain_architectures":2286,"entries":6,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":2286}}}